Post-hoc Data Analysis Demonstrates Natesto’s Restoration of Normal Testosterone Levels in Hypogonadal Men While Maintaining Normal Levels of Estradiol (E2) and Dihydrotestosterone (DHT), Which Are Frequently Altered in Men Treated With Testosterone Replacement Therapy
ENGLEWOOD, CO / ACCESSWIRE / March 20, 2018 / Aytu BioScience, Inc. (AYTU), a specialty life sciences company focused on global commercialization of novel products in the field of urology, today announced that it presented a moderated poster presentation illustrating safety benefits of Natesto therapy restoring normal testosterone levels to hypogonadal men, while maintaining normal, but not high levels of testosterone metabolites estradiol (E2) and dihydrotestosterone (DHT).
The presentation took place on March 18, 2018 at ENDO 2018, the Endocrine Society’s annual meeting and the world’s premier event for presenting and obtaining the latest in endocrine science and medicine.
The presentation details are as follows:
Title: Intranasal Testosterone Therapy (TTh) Produces Normal, Not High, Estradiol (E2) And Dihydrotestosterone (DHT) Levels in Hypogonadal Men
Poster Number: SUN-391
Session: Steroid Biology and Action
Presenter: Alan D. Rogol, MD, University of Virginia, Endocrinology
Conclusion: Treatment with Natesto® restored serum testosterone levels to normal levels in hypogonadal men without excursions above the normal range. 24hr Cavg of both DHT and E2 also returned to normal ranges and illustrates, that with Natesto® treatment, it is unlikely to produce potential adverse events considered secondary to high DHT and E2.
Josh Disbrow, Chief Executive Officer of Aytu BioScience, stated, ”The body of clinical evidence continues to build with Natesto, and this important post hoc analysis from the Natesto Clinical Study Report demonstrates the unique profile of Natesto as it relates to maintaining normal levels of key testosterone metabolites. Both DHT and estradiol levels are frequently altered in men receiving testosterone replacement therapy and can lead to various unwanted side effects, so this analysis identifies a unique aspect to Natesto’s favorable safety profile and may offer distinct benefits to men who are treated with Natesto.”
Selection of the abstracts for publication in the press program does not imply endorsement of Natesto® by the Endocrine Society.
About Aytu BioScience, Inc.
Aytu BioScience is a commercial-stage specialty life sciences company focused on global commercialization of novel products in the field of urology, with a focus on products addressing vitality, sexual wellness, and reproductive health. The Company currently markets two prescription products in the U.S.: Natesto®, the first and only FDA-approved nasal formulation of testosterone for men with hypogonadism (low testosterone, or ”Low T”) and ProstaScint® (capromab pendetide), the only FDA-approved imaging agent specific to prostate specific membrane antigen (PSMA) for prostate cancer detection and staging. Additionally, Aytu is developing MiOXSYS®, a novel, rapid semen analysis system with the potential to become a standard of care for the diagnosis and management of male infertility caused by oxidative stress. MiOXSYS® is commercialized outside the U.S. where it is a CE Marked, Health Canada cleared, Australian TGA approved product, and Aytu is planning U.S.-based clinical trials in pursuit of 510k medical device clearance by the FDA. Aytu’s strategy is to continue building its portfolio of revenue-generating products, leveraging its focused commercial team and expertise to build leading brands within growing markets.
For more information visit www.aytubio.com. Aytu also now wholly-owns its subsidiary Aytu Women’s Health (formerly Nuelle, Inc.), a personal health and wellness company focused on women’s sexual wellbeing and intimacy. Aytu Women’s Health markets Fiera, a personal care product for women that is scientifically proven to enhance physical arousal and sexual desire. Fiera is a consumer product and is not intended to treat, mitigate, or cure any disease or medical condition. For more information about the Fiera personal care product visit fiera.com.
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